The Mouse Metabolic Phenotyping Center
at the Yale University School of Medicine

Relevant Publications

1. Kim JK, Kim Y-J, Fillmore JJ, Chen Y et al. 2001. Prevention of fat-induced insulin resistance by salicylate. J. Clin. Invest. 108:437-446.
2. Kim JK, Zisman A, Fillmore JJ, Peroni OD et al. 2001. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J. Clin. Invest. 108:153-160.
3. Kim JK, Fillmore JJ, Chen Y, Yu C et al. 2001. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl. Acad. Sci. USA 98:7522-7527.
4. Fernandez AM, Kim JK, Yakar S, Dupont J et al. 2001. Functional inactivation of the IGF-1 and insulin receptors in skeletal muscle causes type 2 diabetes. Genes & Dev. 15:1926-1934.
5. Cho H, Mu J, Kim JK, Thorvaldsen JL et al. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBb). Science 292:1728-1731.
6. Zabolotny JM, Kim Y-B, Peroni OD, Kim JK et al. 2001. Overexpression of the leukocyte antigen-related (LAR) protein tyrosine phosphatase in muscle causes insulin resistance. Proc. Natl. Acad. Sci. USA 98:5187-5192.
7. Yang C, Coker KJ, Kim JK, Mora S et al. 2001. Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J. Clin. Invest. 107:1311-1318.
8. Abel ED, Peroni O, Kim JK, Kim Y-B et al. 2001. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409:729-733.
9. Rui L, Aguirre V, Kim JK, Shulman GI et al. 2001. Insulin/IGF-1 and TNF-a stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J. Clin. Invest. 107:181-189.
10. Kim JK, Michael MD, Previs SF, Peroni OD et al. 2000. Redistribution of substrates to adipose tissue in mice with selective insulin resistance in muscle promotes obesity. J. Clin. Invest. 105:1791-1797.
11. Kim JK, Gavrilova O, Chen Y, Reitman ML et al. 2000. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J. Biol. Chem. 275:8456-8460.
12. Klaman LD, Boss O, Peroni OD, Kim JK et al. 2000. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 20:5479-5489.
13. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK et al. 2000. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest. 105:271-278.